Prof. B.K. Thelma:
Dr. JAYA S. TYAGI
India is a land, which from ancient times has been infused with a spirit of inquiry.
Indians have initiated several pioneering and remarkable efforts in the field of
Science in the past as well as during present times, which has been their unique
contribution to the progress of humanity. It is with the desire to commemorate and
salute this Spirit in our women scientists and also to honor their originality of
thought and research that the Stree Shakti Science Samman award has been instituted.
Dr Jaya S. Tyagi is a Professor, All India Institute of Medical Sciences, New Delhi.
Dr. Jaya S. Tyagi has made original contributions to TB research in the areas of
bacterial two-component system (TCS) -mediated signaling during dormancy and development
of versatile diagnostic technologies. These include the discovery of a novel dormancy
drug target, DevR and the development of a small inhibitor molecule targeting DevR.
She discovered the DevR-DevS signal transduction system that is required for bacterial
adaptation during dormancy. Her laboratory has made fundamental contributions towards
characterizing this system particularly in understanding the mechanism of DevR –mediated
transcriptional activation. Novel M. tb strains have also been developed which interfere
with DevR-mediated gene expression and also exhibit profound effects on bacterial
virulence. In addition, a physiologically relevant cell infection model of dormancy
was recently developed in which tubercle bacilli acquire dormancy phenotype within
THP-1 cells. This model is being used at present and is expected to provide, for
the first time, insights into interactions between dormant bacteria and host and
thereby reveal potential targets for therapeutic intervention of dormant organisms.
Furthermore, she has developed a diagnostic toolbox for the efficient laboratory
diagnosis of pulmonary and extra pulmonary TB using highly sensitive smear microscopy,
culture and PCR and antigen detection.
These contributions are published in peer-reviewed journals and several Indian and
International patents to protect the intellectual property have also been awarded.
Stree Shakti is pleased to honour Dr Jaya S. Tyagi with the Stree Shakti Science
Samman, 2012 for her outstanding achievements and technologies developed in TB Research.